Ontology highlight
ABSTRACT:
SUBMITTER: Moriyama B
PROVIDER: S-EPMC5474211 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20170418 1
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 ultrarapid metabolizers have decreased trough voriconazole concentrations, delaying achievement of target blood concentrations; whereas poor metabolizers have increased trough concentrations and are at increased risk of adverse drug events. We summarize evidence from the literature supporting this association and provid ...[more]