Unknown

Dataset Information

0

Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.


ABSTRACT: Obesity and its related metabolic disorders are closely correlated with gut dysbiosis. Montmorillonite is a common medicine used to treat diarrhea. We have previously found that dietary lipid adsorbent-montmorillonite (DLA-M) has an unexpected role in preventing obesity. The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders. Here, we show that DLA-M absorbs free fatty acids (FFA) and endotoxins in vitro and in vivo. Moreover, the combination of fluorescent tracer technique and polarized light microscopy showed that DLA-M crystals immobilized BODIPY® FL C16 and FITC-LPS, respectively, in the digestive tract in situ. HFD-fed mice treated with DLA-M showed mild changes in the composition of the gut microbiota, particularly increases in short-chain fatty acids (SCFA)-producing Blautia bacteria and decreases in endotoxin-producing Desulfovibrio bacteria, these changes were positively correlated with obesity and inflammation. Our results indicated that DLA-M immobilizes FFA and endotoxins in the digestive tract via the adsorption-excretion axis and DLA-M may potentially be used as a prebiotic to prevent intestinal dysbiosis and obesity-associated metabolic disorders in obese individuals.

SUBMITTER: Xu P 

PROVIDER: S-EPMC5474441 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.

Xu Pengfei P   Hong Fan F   Wang Jialin J   Cong Yusheng Y   Dai Shu S   Wang Sheng S   Wang Jing J   Jin Xi X   Wang Fang F   Liu Jin J   Zhai Yonggong Y  

EBioMedicine 20170118


Obesity and its related metabolic disorders are closely correlated with gut dysbiosis. Montmorillonite is a common medicine used to treat diarrhea. We have previously found that dietary lipid adsorbent-montmorillonite (DLA-M) has an unexpected role in preventing obesity. The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders. Here, we show that DLA-M absorbs free fatty acids (FFA) and endoto  ...[more]

Similar Datasets

2009-12-07 | GSE19292 | GEO
| S-EPMC4759552 | biostudies-literature
| S-EPMC4759265 | biostudies-other
| S-EPMC9866798 | biostudies-literature
2024-07-04 | GSE271034 | GEO
| S-EPMC8759188 | biostudies-literature
| S-EPMC10009533 | biostudies-literature
| S-SCDT-10_15252-EMBJ_2022111148 | biostudies-other
| S-EPMC7235719 | biostudies-literature
2018-11-06 | GSE110796 | GEO