Ontology highlight
ABSTRACT:
SUBMITTER: Horscroft JA
PROVIDER: S-EPMC5474778 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Horscroft James A JA Kotwica Aleksandra O AO Laner Verena V West James A JA Hennis Philip J PJ Levett Denny Z H DZH Howard David J DJ Fernandez Bernadette O BO Burgess Sarah L SL Ament Zsuzsanna Z Gilbert-Kawai Edward T ET Vercueil André A Landis Blaine D BD Mitchell Kay K Mythen Monty G MG Branco Cristina C Johnson Randall S RS Feelisch Martin M Montgomery Hugh E HE Griffin Julian L JL Grocott Michael P W MPW Gnaiger Erich E Martin Daniel S DS Murray Andrew J AJ
Proceedings of the National Academy of Sciences of the United States of America 20170522 24
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen delivery in comparison to Lowlander populations have been postulated to play a role in such adaptation. Whether differences in tissue oxygen utilization (i.e., metabolic adaptation) underpin this adaptation is not known, however. We sought to address this issue, applying parallel molecular, biochemical, physiological, and ...[more]