Ontology highlight
ABSTRACT:
SUBMITTER: Tse LV
PROVIDER: S-EPMC5474820 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Tse Longping Victor LV Klinc Kelli A KA Madigan Victoria J VJ Castellanos Rivera Ruth M RM Wells Lindsey F LF Havlik L Patrick LP Smith J Kennon JK Agbandje-McKenna Mavis M Asokan Aravind A
Proceedings of the National Academy of Sciences of the United States of America 20170530 24
Preexisting neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) pose a major, unresolved challenge that restricts patient enrollment in gene therapy clinical trials using recombinant AAV vectors. Structural studies suggest that despite a high degree of sequence variability, antibody recognition sites or antigenic hotspots on AAVs and other related parvoviruses might be evolutionarily conserved. To test this hypothesis, we developed a structure-guided evolution approach that do ...[more]