Ontology highlight
ABSTRACT:
SUBMITTER: Zheng B
PROVIDER: S-EPMC5475247 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20170410 6
The vascular response to pro-atherosclerotic factors is a multifactorial process involving endothelial cells (ECs), macrophages (MACs), and smooth muscle cells (SMCs), although the mechanism by which these cell types communicate with each other in response to environmental cues is yet to be understood. Here, we show that miR-155, which is significantly expressed and secreted in Krüppel-like factor 5 (KLF5)-overexpressing vascular smooth muscle cells (VSMCs), is a potent regulator of endothelium ...[more]