Ontology highlight
ABSTRACT:
SUBMITTER: Gundra UM
PROVIDER: S-EPMC5475284 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature immunology 20170424 6
It remains unclear whether activated inflammatory macrophages can adopt features of tissue-resident macrophages, or what mechanisms might mediate such a phenotypic conversion. Here we show that vitamin A is required for the phenotypic conversion of interleukin 4 (IL-4)-activated monocyte-derived F4/80<sup>int</sup>CD206<sup>+</sup>PD-L2<sup>+</sup>MHCII<sup>+</sup> macrophages into macrophages with a tissue-resident F4/80<sup>hi</sup>CD206<sup>-</sup>PD-L2<sup>-</sup>MHCII<sup>-</sup>UCP1<sup>+< ...[more]