Ontology highlight
ABSTRACT:
SUBMITTER: Akiyama BM
PROVIDER: S-EPMC5476369 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Akiyama Benjamin M BM Laurence Hannah M HM Massey Aaron R AR Costantino David A DA Xie Xuping X Yang Yujiao Y Shi Pei-Yong PY Nix Jay C JC Beckham J David JD Kieft Jeffrey S JS
Science (New York, N.Y.) 20161110 6316
The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called xrRNAs. We found that ZIKV-infected monkey and human epithelial cells, mouse neurons, and mosquito cells produce sfRNAs. The RNA structure that is resp ...[more]