Ontology highlight
ABSTRACT:
SUBMITTER: Anraku K
PROVIDER: S-EPMC5476458 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Anraku Kensaku K Sato Shun S Jacob Nicholas T NT Eubanks Lisa M LM Ellis Beverly A BA Janda Kim D KD
Organic & biomolecular chemistry 20170401 14
Carbohydrate antigens displaying Galα(1,3)Gal epitopes are recognized by naturally occurring antibodies in humans. These anti-Gal antibodies comprise up to 1% of serum IgG and have been viewed as detrimental as they are responsible for hyperacute organ rejections. In order to model this condition, α(1,3)galactosyltransferase-knockout mice are inoculated against the Galα(1,3)Gal epitope. In our study, two α-Gal trisaccharide epitopes composed of either Galα(1,3)Galβ(1,4)GlcNAc or Galα(1,3)Galβ(1, ...[more]