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Interleukins and large domestic animals, a bibliometric analysis.

ABSTRACT: Interleukins have been well described in mice and humans. In large domestic animals the situation is drastically different and there is still a need for further researches aiming at identifying all the homologous interleukins and comparing their functions among species. We performed here a bibliometric analysis of all interleukins described in the literature in various large animal species to identify what is known so far and to underline where there is a need for new studies. Using indicators such as H index but also M quotient, A index, G index, GH ratio, and HG index we ranked 39 interleukins identified so far in bovine, caprine, equine, ovine, and porcine, the main large domestic animals. Indexes and ratio under investigations were higher for IL1, IL2, IL4, IL5, IL6, IL8, IL10, IL12, and IL18 than for other interleukins, particularly in bovine and porcine species and to a certain extent in equine species. Recently discovered interleukins presented low values for the different indexes, quotient, and ratio. Even some "old" interleukins showed low values highlighting the need for further developments in comparative immunology. For instance an interleukin such as IL4 demonstrated variation in its functions between species. In conclusion, this study provides the first bibliometric analysis dedicated to large domestic animal interleukins and underlines the need for more studies to fully determine the structure and the functions of interleukins in other mammal species.

SUBMITTER: Moreau E

PROVIDER: S-EPMC5476471 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Interleukins and large domestic animals, a bibliometric analysis.

Moreau Emmanuelle E Meurens François F

Heliyon 20170615 6

Interleukins have been well described in mice and humans. In large domestic animals the situation is drastically different and there is still a need for further researches aiming at identifying all the homologous interleukins and comparing their functions among species. We performed here a bibliometric analysis of all interleukins described in the literature in various large animal species to identify what is known so far and to underline where there is a need for new studies. Using indicators s ...[more]

PMID: 28653038

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Project description:BackgroundThe most important means of identifying diseases before symptoms appear is through the discovery of disease-associated biomarkers. Recently, microRNAs (miRNAs) have become highly useful biomarkers of infectious, genetic and metabolic diseases in human but they have not been well studied in domestic animals. It is probable that many of the animal homologs of human disease-associated miRNAs may be involved in domestic animal diseases. Here we describe a computational biology study in which human disease miRNAs were utilized to predict orthologous miRNAs in cow, chicken, pig, horse, and dog.ResultsWe identified 287 human disease-associated miRNAs which had at least one 100% identical animal homolog. The 287 miRNAs were associated with 359 human diseases referenced in 2,863 Pubmed articles. Multiple sequence analysis indicated that over 60% of known horse mature miRNAs found perfect matches in human disease-associated miRNAs, followed by dog (50%). As expected, chicken had the least number of perfect matches (5%). Phylogenetic analysis of miRNA precursors indicated that 85% of human disease pre-miRNAs were highly conserved in animals, showing less than 5% nucleotide substitution rates over evolutionary time. As an example we demonstrated conservation of human hsa-miR-143-3p which is associated with type 2 diabetes and targets AKT1 gene which is highly conserved in pig, horse and dog. Functional analysis of AKT1 gene using Gene Ontology (GO) showed that it is involved in glucose homeostasis, positive regulation of glucose import, positive regulation of glycogen biosynthetic process, glucose transport and response to food.ConclusionsThis data provides the animal and veterinary research community with a resource to assist in generating hypothesis-driven research for discovering animal disease-related miRNA from their datasets and expedite development of prophylactic and disease-treatment strategies and also influence research efforts to identify novel disease models in large animals. Integrated data is available for download at http://agbase.hpc.msstate.edu/cgi-bin/animal_mirna.cgi.

Dataset Information

Interleukins and large domestic animals, a bibliometric analysis.

Publications

Interleukins and large domestic animals, a bibliometric analysis.

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