Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC5476507 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Li Bian B Mendenhall Jeffrey J Nguyen Elizabeth Dong ED Weiner Brian E BE Fischer Axel W AW Meiler Jens J
Proteins 20170401 7
One of the challenging problems in tertiary structure prediction of helical membrane proteins (HMPs) is the determination of rotation of α-helices around the helix normal. Incorrect prediction of helix rotations substantially disrupts native residue-residue contacts while inducing only a relatively small effect on the overall fold. We previously developed a method for predicting residue contact numbers (CNs), which measure the local packing density of residues within the protein tertiary structu ...[more]