Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans.

ABSTRACT: The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels

SUBMITTER: Gorobets O 

PROVIDER: S-EPMC5476634 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature