Transcriptomic Analysis on Responses of Murine Lungs to Pasteurella multocida Infection.

ABSTRACT: Pasteurella multocida infection in cattle causes serious epidemic diseases and leads to great economic losses in livestock industry; however, little is known about the interaction between host and P. multocida in the lungs. To explore a fully insight into the host responses in the lungs during P. multocida infection, a mouse model of Pasteurella pneumonia was established by intraperitoneal infection, and then transcriptomic analysis of infected lungs was performed. P. multocida localized and grew in murine lungs, and induced inflammation in the lungs, as well as mice death. With transcriptomic analysis, approximately 10⁷ clean reads were acquired. 4236 differently expressed genes (DEGs) were detected during P. multocida infection, of whi

SUBMITTER: Wu C 

PROVIDER: S-EPMC5476747 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature