Ontology highlight
ABSTRACT:
SUBMITTER: Rasouli SJ
PROVIDER: S-EPMC5477525 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Rasouli S Javad SJ Stainier Didier Y R DYR
Nature communications 20170509
Trabeculation is crucial for cardiac muscle growth in vertebrates. This process requires the Erbb2/4 ligand Neuregulin (Nrg), secreted by the endocardium, as well as blood flow/cardiac contractility. Here, we address two fundamental, yet unresolved, questions about cardiac trabeculation: why does it initially occur in the ventricle and not the atrium, and how is it modulated by blood flow/contractility. Using loss-of-function approaches, we first show that zebrafish Nrg2a is required for trabecu ...[more]