Ontology highlight
ABSTRACT:
SUBMITTER: Maciejowski J
PROVIDER: S-EPMC5477644 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Maciejowski John J Drechsler Hauke H Grundner-Culemann Kathrin K Ballister Edward R ER Rodriguez-Rodriguez Jose-Antonio JA Rodriguez-Bravo Veronica V Jones Mathew J K MJK Foley Emily E Lampson Michael A MA Daub Henrik H McAinsh Andrew D AD Jallepalli Prasad V PV
Developmental cell 20170401 2
The spindle assembly checkpoint kinase Mps1 not only inhibits anaphase but also corrects erroneous attachments that could lead to missegregation and aneuploidy. However, Mps1's error correction-relevant substrates are unknown. Using a chemically tuned kinetochore-targeting assay, we show that Mps1 destabilizes microtubule attachments (K fibers) epistatically to Aurora B, the other major error-correcting kinase. Through quantitative proteomics, we identify multiple sites of Mps1-regulated phospho ...[more]