The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.
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ABSTRACT:
SUBMITTER: Weinberg F
PROVIDER: S-EPMC5478185 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior.
Weinberg Florian F Reischmann Nadine N Fauth Lisa L Taromi Sanaz S Mastroianni Justin J Köhler Martin M Halbach Sebastian S Becker Andrea C AC Deng Niantao N Schmitz Tatjana T Uhl Franziska Maria FM Herbener Nicola N Riedel Bianca B Beier Fabian F Swarbrick Alexander A Lassmann Silke S Dengjel Jörn J Zeiser Robert R Brummer Tilman T
EBioMedicine 20170412
Despite being overexpressed in different tumor entities, RIO kinases are hardly characterized in mammalian cells. We investigated the role of these atypical kinases in different cancer cells. Using isogenic colon-, breast- and lung cancer cell lines, we demonstrate that knockdown of RIOK1, but not of RIOK2 or RIOK3, strongly impairs proliferation and invasiveness in conventional and 3D culture systems. Interestingly, these effects were mainly observed in RAS mutant cancer cells. In contrast, gro ...[more]
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