Ontology highlight
ABSTRACT:
SUBMITTER: Chowdhury S
PROVIDER: S-EPMC5478280 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Chowdhury Saikat S Carter Joshua J Rollins MaryClare F MF Golden Sarah M SM Jackson Ryan N RN Hoffmann Connor C Nosaka Lyn'Al L Bondy-Denomy Joseph J Maxwell Karen L KL Davidson Alan R AR Fischer Elizabeth R ER Lander Gabriel C GC Wiedenheft Blake B
Cell 20170301 1
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and viruses have evolved diverse anti-CRISPR (Acr) proteins that subvert these immune systems. The adaptive immune system in Pseudomonas aeruginosa (type I-F) relies on a 350 kDa CRISPR RNA (crRNA)-guided surveillance complex (Csy complex) to bind foreign DNA and recruit a trans-acting nuclease for target degrad ...[more]