Ontology highlight
ABSTRACT:
SUBMITTER: Brem RB
PROVIDER: S-EPMC547855 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Brem Rachel B RB Kruglyak Leonid L
Proceedings of the National Academy of Sciences of the United States of America 20050119 5
Many studies have identified quantitative trait loci (QTLs) that contribute to continuous variation in heritable traits of interest. However, general principles regarding the distribution of QTL numbers, effect sizes, and combined effects of multiple QTLs remain to be elucidated. Here, we characterize complex genetics underlying inheritance of thousands of transcript levels in a cross between two strains of Saccharomyces cerevisiae. Most detected QTLs have weak effects, with a median variance ex ...[more]