Ontology highlight
ABSTRACT:
SUBMITTER: Jeengar MK
PROVIDER: S-EPMC5478663 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Jeengar Manish Kumar MK Thummuri Dinesh D Magnusson Mattias M Naidu V G M VGM Uppugunduri Srinivas S
Scientific reports 20170620 1
Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation. The aim of the present study was to investigate the potential protective effect of intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation of 3 doses of uridine 1 mg/Kg (lower dose), 5 mg/Kg (medium dose), and 10 mg/Kg (higher dose) in saline ...[more]