Ontology highlight
ABSTRACT:
SUBMITTER: Koch G
PROVIDER: S-EPMC5478890 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Koch Gilbert G Jusko William J WJ Schropp Johannes J
Journal of pharmacokinetics and pharmacodynamics 20170110 1
Target-mediated drug disposition (TMDD) describes drug binding with high affinity to a target such as a receptor. In application TMDD models are often over-parameterized and quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are essential to reduce the number of parameters. However, implementation of such approximations becomes difficult for TMDD models with drug-drug interaction (DDI) mechanisms. Hence, alternative but equivalent formulations are necessary for QE or QSS approxima ...[more]