Membrane Fusion Stalks and Lipid Rafts: A Love-Hate Relationship.
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ABSTRACT:
SUBMITTER: Risselada HJ
PROVIDER: S-EPMC5478936 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Membrane Fusion Stalks and Lipid Rafts: A Love-Hate Relationship.
Biophysical journal 20170516 12
Coarse-grained molecular dynamics simulations are applied to explore the experimentally observed ability of the liquid-ordered (lo)/liquid-disordered (ld) phase boundary to facilitate viral membrane fusion. Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and repelled (i.e., stalkophobic) by the lo/ld phase boundary. The phase boundary becomes stalkophilic if the lo phase constituents have the larger negative spontaneous curvature. In such a case, location of the hi ...[more]
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