Unknown

Dataset Information

0

Membrane Fusion Stalks and Lipid Rafts: A Love-Hate Relationship.


ABSTRACT: Coarse-grained molecular dynamics simulations are applied to explore the experimentally observed ability of the liquid-ordered (lo)/liquid-disordered (ld) phase boundary to facilitate viral membrane fusion. Surprisingly, a formed fusion stalk can be both attracted (i.e., stalkophilic) and repelled (i.e., stalkophobic) by the lo/ld phase boundary. The phase boundary becomes stalkophilic if the lo phase constituents have the larger negative spontaneous curvature. In such a case, location of the highly curved stalk near the less-ordered and thus (relatively) softer boundary region becomes energetically favorable. These insights may explain why modeled viral fusion occurs preferentially near the lo/ld phase boundary.

SUBMITTER: Risselada HJ 

PROVIDER: S-EPMC5478936 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7926437 | biostudies-literature
| S-EPMC373459 | biostudies-literature
| S-EPMC5725944 | biostudies-literature
| S-EPMC6690253 | biostudies-literature
| S-EPMC3020948 | biostudies-literature
| S-EPMC4226129 | biostudies-literature
| S-EPMC4518042 | biostudies-literature
| S-EPMC3656094 | biostudies-literature
| S-EPMC5500228 | biostudies-literature
| S-EPMC5922362 | biostudies-literature