Ontology highlight
ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC5479268 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Meng Xiaoqing X Yang Yueting Y Zhou Lihua L Zhang Li L Lv Yalin Y Li Sanpeng S Wu Yayun Y Zheng Mingbin M Li Wenjun W Gao Guanhui G Deng Guanjun G Jiang Tao T Ni Dapeng D Gong Ping P Cai Lintao L
Theranostics 20170410 7
The precision oncology significantly relies on the development of multifunctional agents to integrate tumor targeting, imaging and therapeutics. In this study, a first small-molecule theranostic probe, RhoSSCy is constructed by conjugating 5'-carboxyrhodamines (Rho) and heptamethine cyanine IR765 (Cy) using a reducible disulfide linker and pH tunable amino-group to realize thiols/pH dual sensing. <i>In vitro</i> experiments verify that RhoSSCy is highly sensitive for quantitative analysis and im ...[more]