Ontology highlight
ABSTRACT:
SUBMITTER: Heitzig N
PROVIDER: S-EPMC5479451 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Heitzig Nicole N Brinkmann Benjamin F BF Koerdt Sophia N SN Rosso Gonzalo G Shahin Victor V Rescher Ursula U
Cell adhesion & migration 20170106 3
The physiological and pathological process of angiogenesis relies on orchestrated endothelial cell (EC) adhesion, migration and formation of new vessels. Here we report that human umbilical vein endothelial cells (HUVECs) deficient in Annexin A8 (AnxA8), a member of the annexin family of Ca<sup>2+</sup>- and membrane binding proteins, are strongly deficient in their ability to sprout in response to vascular endothelial growth factor (VEGF)-A, and are strongly impaired in their ability to migrate ...[more]