Ontology highlight
ABSTRACT:
SUBMITTER: Patke A
PROVIDER: S-EPMC5479574 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Patke Alina A Murphy Patricia J PJ Onat Onur Emre OE Krieger Ana C AC Özçelik Tayfun T Campbell Scott S SS Young Michael W MW
Cell 20170401 2
Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ∼24 hr rhythms in many behavioral and physiological processes. This system is altered in delayed sleep phase disorder (DSPD), a common form of insomnia in which sleep episodes are shifted to later times misaligned with the societal norm. Here, we report a hereditary form of DSPD associated with a dominant coding variation in the core circadian clock gene CRY1, which creates a transcriptional inhibitor w ...[more]