Ontology highlight
ABSTRACT:
SUBMITTER: Iracheta-Vellve A
PROVIDER: S-EPMC5479767 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Iracheta-Vellve Arvin A Petrasek Jan J Gyogyosi Benedek B Bala Shashi S Csak Timea T Kodys Karen K Szabo Gyongyi G
Liver international : official journal of the International Association for the Study of the Liver 20170427 7
<h4>Background & aims</h4>Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.<h4>Methods</h4>In this study, we tested IL-1 receptor antagonist to block IL-1 signalling in a mouse model of acute-on-chronic liver injury on liver inflammation and hepatocyte regenera ...[more]