Ontology highlight
ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC5479937 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Tang Xiaoying X Holland Dominic D Dale Anders M AM Miller Michael I MI
Journal of Alzheimer's disease : JAD 20150101 3
This paper examines how age intervenes in the effects of APOE ɛ4 allele on the volume and shape morphometrics of the hippocampus and the amygdala in mild cognitive impairment (MCI) and Alzheimer's disease. We evaluate the structural morphological differences between ɛ4 carriers and non-carriers in two age-dependent subgroups; younger than 75 years (Young-Old) and older than 80 years (Very-Old). While we show that the four structures of interest atrophy significantly in the ɛ4 carriers, relative ...[more]