Dataset Information

The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.

ABSTRACT:

Aim

The effect of a gene-expression-based test on treatment of melanocytic neoplasms by dermatologists was evaluated.

Patients & methods

Pathologists submitted diagnostically challenging melanocytic neoplasms to a clinical laboratory for testing accompanied by pretest surveys documenting the intended treatment recommendations. The actual treatment rendered by dermatologists was then documented after testing. Changes between the pretest recommendations and actual treatment were analyzed.

Results

In 71.4% (55/77) of cases, there was a change from pretest recommendations to actual treatment. The majority of changes were consistent with the test result. There was an 80.5% (33/41) reduction in the number of biopsy site re-excisions performed for cases with a benign test result.

Conclusion

The actual treatment of diagnostically challenging melanocytic neoplasms is influenced by the test.

SUBMITTER: Cockerell C

PROVIDER: S-EPMC5480781 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Publications

The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.

Cockerell Clay C Tschen Jaime J Billings Steven D SD Evans Brent B Brown Krystal K Rock Colleen C Clarke Loren E LE

Personalized medicine 20170123 2

<h4>Aim</h4>The effect of a gene-expression-based test on treatment of melanocytic neoplasms by dermatologists was evaluated.<h4>Patients & methods</h4>Pathologists submitted diagnostically challenging melanocytic neoplasms to a clinical laboratory for testing accompanied by pretest surveys documenting the intended treatment recommendations. The actual treatment rendered by dermatologists was then documented after testing. Changes between the pretest recommendations and actual treatment were ana ...[more]

PMID: 28757886

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Dataset Information

The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.

Aim

Patients & methods

Results

Conclusion

Publications

The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions.

Similar Datasets

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