Ontology highlight
ABSTRACT:
SUBMITTER: Martin EM
PROVIDER: S-EPMC5480787 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Martin Elizabeth M EM Stýblo Miroslav M Fry Rebecca C RC
Epigenomics 20170504 5
Chronic exposure to arsenic has been associated with the development of diabetes mellitus (DM), a disease characterized by hyperglycemia resulting from dysregulation of glucose homeostasis. This review summarizes four major mechanisms by which arsenic induces diabetes, namely inhibition of insulin-dependent glucose uptake, pancreatic β-cell damage, pancreatic β-cell dysfunction and stimulation of liver gluconeogenesis that are supported by both in vivo and in vitro studies. Additionally, the rol ...[more]