Cholic acid-based novel micellar nanoplatform for delivering FDA-approved taxanes.
Ontology highlight
ABSTRACT: Aim
To structurally modify our existing cholic acid (CA)-based telodendrimer (TD; PEG5K-CA8) for effective micellar nanoencapsulation and delivery of the US FDA-approved members of taxane family.Materials & methods
Generation of hybrid TDs was achieved by replacing four of the eight CAs with biocompatible organic moieties using solution-phase peptide synthesis. Drug loading was done using the standard evaporation method.Results
Hybrid TDs can generate micelles with narrow size distributions, low critical micelle concentration values (1-6 μM), better hematocompatibility and lack of in vitro cytotoxicity.Conclusion
Along with PEG5K-CA8, CA-based hybrid nanoplatform is the first of its kind that can stably encapsulate all three FDA-approved taxanes with nearly 100% efficiency up to 20% (w/w) loading.
SUBMITTER: Bharadwaj G
PROVIDER: S-EPMC5480805 | biostudies-literature |
REPOSITORIES: biostudies-literature
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