Ontology highlight
ABSTRACT:
SUBMITTER: Lee ES
PROVIDER: S-EPMC5480859 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Lee Eun Soo ES Lee Mi Young MY Kwon Mi-Hye MH Kim Hong Min HM Kang Jeong Suk JS Kim You Mi YM Lee Eun Young EY Chung Choon Hee CH
PloS one 20170622 6
The aim of this study was to evaluate the effects of sarpogrelate hydrochloride (SH), a selective serotonin 2A receptor antagonist, on diabetic nephropathy in a type 2 diabetes mouse model. We treated db/m and db/db mice with SH (30 mg/kg/day) for 12 weeks. Rat renal proximal tubule cells (NRK-52E) and mouse macrophages (Raw 264.7) were stimulated by high glucose (30 mM glucose) or LPS (100 ng/ml) with or without SH (20 μM). We found that SH treatment increased serum adiponectin level and decrea ...[more]