Dataset Information

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis.

ABSTRACT: Psoriasis is an immune-mediated inflammatory skin disease that has been associated with cutaneous microbial dysbiosis by culture-dependent investigations and rRNA community profiling. We applied, for the first time, high-resolution shotgun metagenomics to characterise the microbiome of psoriatic and unaffected skin from 28 individuals. We demonstrate psoriatic ear sites have a decreased diversity and psoriasis is associated with an increase in Staphylococcus, but overall the microbiomes of psoriatic and unaffected sites display few discriminative features at the species level. Finer strain-level analysis reveals strain heterogeneity colonisation and functional variability providing the intriguing hypothesis of psoriatic niche-specific strain adaptation or selection. Furthermore, we accessed the poorly characterised, but abundant, clades with limited sequence information in public databases, including uncharacterised Malassezia spp. These results highlight the skins hidden diversity and suggests strain-level variations could be key determinants of the psoriatic microbiome. This illustrates the need for high-resolution analyses, particularly when identifying therapeutic targets. This work provides a baseline for microbiome studies in relation to the pathogenesis of psoriasis.

SUBMITTER: Tett A

PROVIDER: S-EPMC5481418 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis.

Tett Adrian A Pasolli Edoardo E Farina Stefania S Truong Duy Tin DT Asnicar Francesco F Zolfo Moreno M Beghini Francesco F Armanini Federica F Jousson Olivier O De Sanctis Veronica V Bertorelli Roberto R Girolomoni Giampiero G Cristofolini Mario M Segata Nicola N

NPJ biofilms and microbiomes 20170622

Psoriasis is an immune-mediated inflammatory skin disease that has been associated with cutaneous microbial dysbiosis by culture-dependent investigations and rRNA community profiling. We applied, for the first time, high-resolution shotgun metagenomics to characterise the microbiome of psoriatic and unaffected skin from 28 individuals. We demonstrate psoriatic ear sites have a decreased diversity and psoriasis is associated with an increase in <i>Staphylococcus</i>, but overall the microbiomes o ...[more]

PMID: 28649415

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Dataset Information

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis.

Publications

Unexplored diversity and strain-level structure of the skin microbiome associated with psoriasis.

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