Perceived cognitive function for breast cancer survivors: association of genetic and behaviorally related variables for inflammation.

ABSTRACT:

Purpose

We explored relationships between genetic variability and behaviorally related variables (body mass index and exercise frequency) for inflammation, and perceived cognitive function (PCF) for breast cancer survivors (BCS). Our primary aim was to explore relationships between select single-nucleotide polymorphisms (SNPs) for IL1R1, IL6, TNF genes, and PCF. Our secondary aim was to explore whether body mass index (BMI) and exercise frequency moderate these relationships.

Methods

We conducted an exploratory candidate gene substudy. Saliva samples from participants (N = 101) in a larger, cross-sectional study were genotyped. Multiple linear regression analysis was used to explore relationships between SNPs and PCF, controlling for age, education level, fatigue, and distre

SUBMITTER: Myers JS 

PROVIDER: S-EPMC5481483 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature