Myelin volume fraction imaging with MRI.
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ABSTRACT:
SUBMITTER: West KL
PROVIDER: S-EPMC5481512 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Myelin volume fraction imaging with MRI.
West Kathryn L KL Kelm Nathaniel D ND Carson Robert P RP Gochberg Daniel F DF Ess Kevin C KC Does Mark D MD
NeuroImage 20161223
MRI is a valuable tool to assess myelin during development and demyelinating disease processes. While multiexponential T<sub>2</sub> and quantitative magnetization transfer measures correlate with myelin content, neither provides the total myelin volume fraction. In many cases correlative measures are adequate; but to assess microstructure of myelin, (e.g. calculate the g-ratio using MRI), an accurate measure of myelin volume fraction is imperative. Using a volumetric model of white matter, we r ...[more]
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