Ontology highlight
ABSTRACT:
SUBMITTER: Kugel S
PROVIDER: S-EPMC5481743 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Kugel Susann S Baunach Martin M Baer Philipp P Ishida-Ito Mie M Sundaram Srividhya S Xu Zhongli Z Groll Michael M Hertweck Christian C
Nature communications 20170615
Terpenoid natural products comprise a wide range of molecular architectures that typically result from C-C bond formations catalysed by classical type I/II terpene cyclases. However, the molecular diversity of biologically active terpenoids is substantially increased by fully unrelated, non-canonical terpenoid cyclases. Their evolutionary origin has remained enigmatic. Here we report the in vitro reconstitution of an unusual flavin-dependent bacterial indoloterpenoid cyclase, XiaF, together with ...[more]