Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC5482062 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Huang Weishan W Solouki Sabrina S Koylass Nicholas N Zheng Song-Guo SG August Avery A
Nature communications 20170621
Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance. Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system during parasitic and viral infections. ITK kinase activity is required for mouse and human T ...[more]