Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC5482078 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Xu Huichun H Ryan Kathleen A KA Jaworek Thomas J TJ Southam Lorraine L Reid Jeffrey G JG Overton John D JD Baras Aris A Puurunen Marja K MK Zeggini Eleftheria E Taylor Simeon I SI Shuldiner Alan R AR Mitchell Braxton D BD
Diabetes 20170420 7
Alleles associated with lower levels of LDL cholesterol (LDL-C) have recently been associated with an increased risk of type 2 diabetes (T2D), highlighting the complex relationship between LDL-C and diabetes. This observation begs the question of whether LDL-C-raising alleles are associated with a decreased risk of T2D. This issue was recently addressed in a large familial hypercholesterolemia (FH) screening study, which reported a lower prevalence of self-reported diabetes in FH subjects than i ...[more]