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Large-field-of-view imaging by multi-pupil adaptive optics.

ABSTRACT: Adaptive optics can correct for optical aberrations. We developed multi-pupil adaptive optics (MPAO), which enables simultaneous wavefront correction over a field of view of 450 × 450 ?m2 and expands the correction area to nine times that of conventional methods. MPAO's ability to perform spatially independent wavefront control further enables 3D nonplanar imaging. We applied MPAO to in vivo structural and functional imaging in the mouse brain.

SUBMITTER: Park JH

PROVIDER: S-EPMC5482233 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Large-field-of-view imaging by multi-pupil adaptive optics.

Park Jung-Hoon JH Kong Lingjie L Zhou Yifeng Y Cui Meng M

Nature methods 20170508 6

Adaptive optics can correct for optical aberrations. We developed multi-pupil adaptive optics (MPAO), which enables simultaneous wavefront correction over a field of view of 450 × 450 μm<sup>2</sup> and expands the correction area to nine times that of conventional methods. MPAO's ability to perform spatially independent wavefront control further enables 3D nonplanar imaging. We applied MPAO to in vivo structural and functional imaging in the mouse brain. ...[more]

PMID: 28481364

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