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Fragmentation of the mitochondrial network in skin in vivo.

ABSTRACT: Mitochondria form dynamic networks which adapt to the environmental requirements of the cell. We investigated the aging process of these networks in human skin cells in vivo by multiphoton microscopy. A study on the age-dependency of the mitochondrial network in young and old volunteers revealed that keratinocytes in old skin establish a significantly more fragmented network with smaller and more compact mitochondrial clusters than keratinocytes in young skin. Furthermore, we investigated the mitochondrial network during differentiation processes of keratinocytes within the epidermis of volunteers. We observe a fragmentation similar to the age-dependent study in almost all parameters. These parallels raise questions about the dynamics of biophysical network structures during aging processes.

SUBMITTER: Mellem D

PROVIDER: S-EPMC5482427 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Fragmentation of the mitochondrial network in skin in vivo.

Mellem Daniel D Sattler Martin M Pagel-Wolff Sonja S Jaspers Sören S Wenck Horst H Rübhausen Michael Alexander MA Fischer Frank F

PloS one 20170623 6

Mitochondria form dynamic networks which adapt to the environmental requirements of the cell. We investigated the aging process of these networks in human skin cells in vivo by multiphoton microscopy. A study on the age-dependency of the mitochondrial network in young and old volunteers revealed that keratinocytes in old skin establish a significantly more fragmented network with smaller and more compact mitochondrial clusters than keratinocytes in young skin. Furthermore, we investigated the mi ...[more]

PMID: 28644888

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