Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data.

ABSTRACT: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD).To examine whether exercise habits were associated with changes in HRQL and mobility over two years.We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson's Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG). We compared self-reported regular exercisers (?2.5 hours/week) with people who did not exercise 2.5 hours/week. Then we quantified changes in HRQL and mobility associated with 30-minute increases in exercise, across PD severity, using mixed effects regression models.Participants with three observational study visits (n?=?3408) were younger, with milder PD, than participants with fewer visits. After 2 years, consistent exercisers and people who started to exercise regularly after their baseline visit had smaller declines in HRQL and mobility than non-exercisers (p?

SUBMITTER: Rafferty MR 

PROVIDER: S-EPMC5482526 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature