Ontology highlight
ABSTRACT:
SUBMITTER: Calegari MA
PROVIDER: S-EPMC5482728 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Calegari M A MA Inno A A Monterisi S S Orlandi A A Santini D D Basso M M Cassano A A Martini M M Cenci T T de Pascalis I I Camarda F F Barbaro B B Larocca L M LM Gori S S Tonini G G Barone C C
British journal of cancer 20170420 10
<h4>Background</h4>Presently, few options are available for refractory colorectal cancer (CRC). O6-methyl-guanine-DNA-methyltransferase (MGMT) promoter methylation is a frequent and early event in CRC tumourigenesis. This epigenetic silencing is a predictor of response to the alkylating drug temozolomide in glioblastoma. Preclinical evidences and some case reports showed temozolomide activity in CRC with MGMT silencing, but the available data from clinical trials are inconsistent.<h4>Methods</h4 ...[more]