Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G.
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ABSTRACT:
SUBMITTER: Lin JLJ
PROVIDER: S-EPMC5483177 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G.
Lin Jason L J JLJ Nakagawa Akihisa A Skeen-Gaar Riley R Yang Wei-Zen WZ Zhao Pei P Zhang Zhe Z Ge Xiao X Mitani Shohei S Xue Ding D Yuan Hanna S HS
Cell reports 20160623 2
Endonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C. elegans through an EndoG-mediated cell-death pathway. In response to high reactive oxygen species (ROS) levels, homodimeric CPS-6-the C. elegans homolog of EndoG-is dissociated into monomers with diminished nuclease activity. Conversely, the nuclease activi ...[more]
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