Latent Cytomegalovirus (CMV) Infection Does Not Detrimentally Alter T Cell Responses in the Healthy Old, But Increased Latent CMV Carriage Is Related to Expanded CMV-Specific T Cells.

ABSTRACT: Human cytomegalovirus (HCMV) primary infection and periodic reactivation of latent virus is generally well controlled by T-cell responses in healthy people. In older donors, overt HCMV disease is not generally seen despite the association of HCMV infection with increased risk of mortality. However, increases in HCMV DNA in urine of older people suggest that, although the immune response retains functionality, immunomodulation of the immune response due to lifelong viral carriage may alter its efficacy. Viral transcription is limited during latency to a handful of viral genes and there is both an IFNγ and cellular IL-10 CD4⁺ T-cell response to HCMV latency-associated proteins. Production of cIL-10 by HCMV-specific CD4⁺ T-cells is a candidate for aging-related immunomod

SUBMITTER: Jackson SE 

PROVIDER: S-EPMC5483450 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature