Ontology highlight
ABSTRACT:
SUBMITTER: Podobnik M
PROVIDER: S-EPMC5483512 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Podobnik Marjetka M Kisovec Matic M Anderluh Gregor G
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20170801 1726
Aerolysin-like pore-forming proteins are an important family of proteins able to efficiently damage membranes of target cells by forming transmembrane pores. They are characterized by a unique domain organization and mechanism of action that involves extensive conformational rearrangements. Although structures of soluble forms of many different members of this family are well understood, the structures of pores and their mechanism of assembly have been described only recently. The pores are char ...[more]