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Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.

ABSTRACT: Inactivation of the small guanosine triphosphate-binding protein Ras during receptor signal transduction is mediated by Ras guanosine triphosphatase (GTPase)-activating proteins (RasGAPs). Ten different RasGAPs have been identified and have overlapping patterns of tissue distribution. However, genetic analyses are revealing critical nonredundant functions for each RasGAP in tissue homeostasis and as regulators of disease processes in mouse and man. Here, we discuss advances in understanding the role of RasGAPs in the maintenance of tissue integrity.

SUBMITTER: King PD

PROVIDER: S-EPMC5483993 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis.

King Philip D PD Lubeck Beth A BA Lapinski Philip E PE

Science signaling 20130226 264

Inactivation of the small guanosine triphosphate-binding protein Ras during receptor signal transduction is mediated by Ras guanosine triphosphatase (GTPase)-activating proteins (RasGAPs). Ten different RasGAPs have been identified and have overlapping patterns of tissue distribution. However, genetic analyses are revealing critical nonredundant functions for each RasGAP in tissue homeostasis and as regulators of disease processes in mouse and man. Here, we discuss advances in understanding the ...[more]

PMID: 23443682

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