Ontology highlight
ABSTRACT:
SUBMITTER: Orchard RC
PROVIDER: S-EPMC5484048 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160818 6302
Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host molecules that are essential for murine NoV (MNoV)-induced cell death, including CD300lf as a proteinaceous receptor. We found that CD300lf is essential for MNoV binding and replication in cell lines and primary cells. Additionally, Cd300lf(-/-) mice are resistant to MNoV infection. Expression of CD300lf in human cells breaks the species ba ...[more]