Ontology highlight
ABSTRACT:
SUBMITTER: Fletcher RB
PROVIDER: S-EPMC5484588 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Fletcher Russell B RB Das Diya D Gadye Levi L Street Kelly N KN Baudhuin Ariane A Wagner Allon A Cole Michael B MB Flores Quetzal Q Choi Yoon Gi YG Yosef Nir N Purdom Elizabeth E Dudoit Sandrine S Risso Davide D Ngai John J
Cell stem cell 20170511 6
A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis. Adult stem cells maintain and regenerate multiple mature cell lineages in the olfactory epithelium. Here we integrate single-cell RNA sequencing and robust statistical analyses with in vivo lineage tracing to define a detailed map of the postnatal olfactory epithelium, revealing cell fate potentials and branchpoint ...[more]