Ontology highlight
ABSTRACT:
SUBMITTER: Lee YK
PROVIDER: S-EPMC5484644 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Lee Young-Kwan YK Kang Myungsoo M Choi Eun Young EY
Immune network 20170620 3
Graft-versus-host disease (GHVD) is a severe complication after allogeneic hematopoietic stem cell transplantation. The degree of inflammation in the gastrointestinal tract, a major GVHD target organ, correlates with the disease severity. Intestinal inflammation is initiated by epithelial damage caused by pre-conditioning irradiation. In combination with damages caused by donor-derived T cells, such damage disrupts the epithelial barrier and exposes innate immune cells to pathogenic and commensa ...[more]