Ontology highlight
ABSTRACT:
SUBMITTER: Sjoberg LC
PROVIDER: S-EPMC5484710 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Sjöberg L C LC Nilsson A Zoltowska AZ Lei Y Y Gregory J A JA Adner M M Nilsson G P GP
Scientific reports 20170626 1
Interleukin 33 (IL-33) represents a potential link between the airway epithelium and induction of Th2-type inflammatory responses associated with the development of asthma. This study investigated the potential of IL-33 to exacerbate antigen driven asthma responses. An ovalbumin (OVA) asthma model was used in which sensitized C57BL/6 mice were exposed to IL-33 before each OVA challenge. IL-33 given to sensitized mice acted synergistically with antigen and aggravated airway inflammation, hyperres ...[more]