Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct.

ABSTRACT:

Background and aims

The effects of glucocorticoids on fuel metabolism are complex. Acute glucocorticoid excess promotes lipolysis but chronic glucocorticoid excess causes visceral fat accumulation. We hypothesized that interactions between cortisol and insulin and adrenaline account for these conflicting results. We tested the effect of cortisol on lipolysis and glucose production with and without insulin and adrenaline in humans both in vivo and in vitro.

Materials and methods

A total of 20 healthy men were randomized to low and high insulin groups (both n = 10). Subjects attended on 3 occasions and received low (c. 150 nM), medium (c. 400 nM) or high (c. 1400 nM) cortisol infusion in a randomized crossover design. Deuterated glucose and glycerol were infused intravenously

SUBMITTER: Stimson RH 

PROVIDER: S-EPMC5484992 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature