Ontology highlight
ABSTRACT:
SUBMITTER: Heise T
PROVIDER: S-EPMC5485013 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Heise Tim T Nørskov Marianne M Nosek Leszek L Kaplan Kadriye K Famulla Susanne S Haahr Hanne L HL
Diabetes, obesity & metabolism 20170423 7
<h4>Aim</h4>To compare day-to-day and within-day variability in glucose-lowering effect between insulin degludec (IDeg) and insulin glargine 300 U/mL (IGlar-U300) in type 1 diabetes.<h4>Materials and methods</h4>In this double-blind, crossover study, patients were randomly assigned to 0.4 U/kg of IDeg or IGlar-U300 once daily for two treatment periods lasting 12 days each. Pharmacodynamic variables were assessed at steady-state from the glucose infusion rate profiles of three 24-hour euglycaemic ...[more]