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Insulin degludec: Lower day-to-day and within-day variability in pharmacodynamic response compared with insulin glargine 300?U/mL in type 1 diabetes.


ABSTRACT: AIM:To compare day-to-day and within-day variability in glucose-lowering effect between insulin degludec (IDeg) and insulin glargine 300?U/mL (IGlar-U300) in type 1 diabetes. MATERIALS AND METHODS:In this double-blind, crossover study, patients were randomly assigned to 0.4?U/kg of IDeg or IGlar-U300 once daily for two treatment periods lasting 12?days each. Pharmacodynamic variables were assessed at steady-state from the glucose infusion rate profiles of three 24-hour euglycaemic glucose clamps (days 6, 9 and 12) during each treatment period. RESULTS:Overall, 57 patients completed both treatment periods (342 clamps). The potency of IGlar-U300 was 30% lower than IDeg (estimated ratio 0.70, 95% confidence interval [CI] 0.61; 0.80; P ?

SUBMITTER: Heise T 

PROVIDER: S-EPMC5485013 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Insulin degludec: Lower day-to-day and within-day variability in pharmacodynamic response compared with insulin glargine 300 U/mL in type 1 diabetes.

Heise Tim T   Nørskov Marianne M   Nosek Leszek L   Kaplan Kadriye K   Famulla Susanne S   Haahr Hanne L HL  

Diabetes, obesity & metabolism 20170423 7


<h4>Aim</h4>To compare day-to-day and within-day variability in glucose-lowering effect between insulin degludec (IDeg) and insulin glargine 300 U/mL (IGlar-U300) in type 1 diabetes.<h4>Materials and methods</h4>In this double-blind, crossover study, patients were randomly assigned to 0.4 U/kg of IDeg or IGlar-U300 once daily for two treatment periods lasting 12 days each. Pharmacodynamic variables were assessed at steady-state from the glucose infusion rate profiles of three 24-hour euglycaemic  ...[more]

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