Ontology highlight
ABSTRACT:
SUBMITTER: Nanduri B
PROVIDER: S-EPMC5485257 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nanduri Bindu B Suvarnapunya Akamol E AE Venkatesan Malabi M Edelmann Mariola J MJ
Current pharmaceutical design 20130101 18
Deubiquitinating enzymes (DUBs) remove ubiquitin and ubiquitin-like modifications from proteins and they have been known to contribute to processes relevant in microbial infection, such as immune responses pathways. Numerous viral and bacterial DUBs have been identified, and activities of several host DUBs are known to be modulated during the infection process, either by a pathogen or by a host. Recently there have been attempts to take advantage of this feature and design therapeutic inhibitors ...[more]